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In some, as the disease progresses, despite titration of the basal insulin to correct fasting hyperglycaemia (typically more than 0.5 U/kg), mealtime insulin may have to be added to meet glycaemic targets, particularly postprandial glucose [328]

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Therapeutic implications: context-specific applications The efficacy of antiangiogenic therapies is highly dependent on their application in the appropriate pathological contexts

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