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One important caveat: that study delivered GHK-Cu via lipid-based nano-carriers - a specialist liposomal delivery system designed to maximise dermal penetration

BMC Immunol 2017, 18 (1), 33

Its functions help to increase cellular metabolism and energy production while reducing the negative consequences of oxidative damage

Antioxidant Depletion: In an ironnitrilotriacetic acid rat model of hemochromatosis, renal samples showed increases in reactive intermediates, accompanied by decreased availability of systems that protect against oxidation by iron, such as vitamin E levels, the glutathione system, thiol-specific antioxidants, and superoxide dismutase

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We suggest that the genomic context of the cntA gene must be also taken into account