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Briefly, the shelterin genes encoding TRF1 (NM_017489.2), TRF2 (NM_005652.4), RAP1 (NM_018975.3), TPP1 (BC016904.1), POT1 (NM_015450) and (StrepII) 2 -TEV-tagged TIN2 (NM_001099274.1) were codon-optimised for E

One commenter suggested using clusters but maintaining cost and frequency thresholds, further suggesting using eligibility for Transitional Pass-Through payment as one criterion by which to identify instances where a code cluster would be appropriate for an expanded complexity adjustment