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However, the TMD-binding cavity is even more open in the presence of exendin-P5, due to a more outward location of TM7

As discussed in this review, this complex tissue-specific regulation of LPL activity is physiologically desirable

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To verify this assumption, an in vitro experiment was conducted using two murine cell types (chondrocytes and macrophages), which reflect two crucial cell types present in knee joints

References Graybill S, Hatfield J, Kravchenko M, Beckman D, Tate J, Beauvais A, et al