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The beneficial effects of GLP-1RAs on mitochondrial function may be mediated via the activation of pathways involved in the regulation of mitochondrial function, including the AMP-activated protein kinase (AMPK) pathway (a major regulator of mitochondrial biogenesis) and the peroxisome-proliferator-activated receptor gamma coactivator 1-alpha (PGC-1) [97,98]

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J Appl Physiol 92:394400