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Poisson L, Blank I, Dunkel A, & Hofmann T

Through integrated transcriptomic and metabolic analyses, we found that NOTCH1 -mutated cells exhibit a distinct bioenergetic profile, characterized by upregulation of mitochondrial programs, enhanced oxidative phosphorylation, and elevated ROS production, all hallmarks of an active mitochondrial phenotype (Figs

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Subsequently, we evaluated the inhibitory effects of the DNA-PKcs inhibitor KU-57788 in five ATC cell lines using the CCK8 assay