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Hypothyroidism occurs when the thyroid gland produces insufficient thyroid hormones, affecting approximately 4-8% of the US population (with overt hypothyroidism affecting 0.3-0.5%)

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35839643) Renal failure, including dialysis : Generally, no dose adjustment is required

Weight loss outcomes : Semaglutide at the doses used for weight management (Wegovy, 2.4 mg weekly) has produced average weight loss of 15-17% of body weight over 68 weeks in clinical trials (STEP program)