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Table 1 Advantages and disadvantages of bloodbrain barrier permeability assessment methods

Participants were excluded if they had significant medical histories, abnormal lab results, or conditions affecting alcohol metabolism or absorption of the investigational product

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However, comprehensive human pharmacokinetic data remain limited, underscoring reliance on standardized extracts such as SHR-5 with defined rosavin-to-salidroside ratios (99, 101, 102)

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