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In the SURMOUNT-1 trial, participants on the highest dose of tirzepatide lost an average of 22.5 percent of their body weight at 72 weeks (Jastreboff et al., NEJM , 2022), compared to roughly 15 percent with semaglutide 2.4 mg in the STEP 1 trial (Wilding et al., NEJM , 2021)

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2), and its underlying mechanism was analyzed for p47Phox, which was examined to evaluate the protective effect of l-Carnitine on the level of p47Phox induced by PFOS treatment through a Western blot analysis