Development of GLP-1MK-801 To safely harness the weight-lowering properties of NMDA receptor antagonism, we developed a targeting approach based on the hypothesis that conjugation of MK-801 to a GLP-1 analogue through a chemically cleavable disulfide linker would enhance the therapeutic potential of NMDA receptor antagonism in appetite-regulating brain regions enriched for GLP-1 receptors, while mitigating the adverse effects related to the non-restricted actions of MK-801
Hannafin et al., Effect of stress deprivation and cyclic tensile loading on the material and morphologic properties of canine flexor digitorum profundus tendon: an in vitro study, Journal of orthopaedic research : official publication of the Orthopaedic Research Society 13, no
Nat Commun 9:3632
PQQ supports mitochondrial biogenesisthe process of creating new mitochondriathrough pathways involving PGC-1, a key regulator of mitochondrial production and cellular energy metabolism
Recently, a significant body of evidence has demonstrated the anti-proliferative and chemotherapeutic effects of fluvastatin in LC
114 Two recent studies revealed elevated serum levels of iron and ferritin associated with cerebral ischemia or disease severity in COVID-19 patients
