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Consider prescribing naloxone, based on the patients risk factors for overdose, such as concomitant use of other CNS depressants, a history of opioid use disorder, or prior opioid overdose

(2010) 202:171.e1171.e11

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It is common for patients to use several NSAIDs without proper knowledge of the consequences of such behavior and without medical consultation, which limits control over their safe use

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Later, a Science investigation raised suspicions, presenting evidence that Sylvain Lesn, a professor in UMN's Department of Neurology, who was Ashe's protg and the paper's first author, used manipulated data not only in the Nature paper but in other publications as well