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Finally, NEergic system is affected very early from AD pathology so a mechanism in which neuroinflammation and NEergic system degeneration could lead to a disruption of neural metabolism resulting in CNS wide dysregulation of neurotransmission, ultimately leading to cognitive deficits characteristic of AD

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Given the abundance of RBCs in blood, erythrocytes have been reported to produce up to 40% of thrombin in certain pathological conditions [47, 49, 50]

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