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Be Mindful of Timing Some people find that taking their dose in the evening allows them to sleep through the initial peak of nausea

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References Marzook, A., Tomas, A., & Jones, B

Always tell your doctor about all medications

Mechanistically, this was explained by dehydration caused by nausea, vomiting and diarrhea (see above)

The effect of semaglutide compared to placebo on estimated diastolic blood pressure was calculated using a MMRM model with two-sided P-values and with fixed effects for treatment, visit, baseline log-transformed UACR, the interaction between treatment and visit, and the interaction between baseline and diastolic blood pressure