IV is used clinically but requires proper setup Cycle: 5 days on, 2 days off for 48 weeks, then 4-week break Neuroprotection / Anti-Aging Stack Dose: 5mL/day (lower end) for 1020 day cycles Pair with: Semax (BDNF potentiation), BPC-157 (gut-brain axis), NAD+ (mitochondrial support) TBI Recovery or Post-Stroke Clinical doses run 1030mL/day IV this requires medical supervision Biohacking context: 10mL subQ/day for 20-day cycles is common in self-research reports My Current Approach Starting at the low end (510mg of lyophilized equivalent subQ) for the first week, then scaling based on cognitive response
In September 2022, Eli Lilly published the results of its preclinical studies on LY3437943 in the journal Cell Metabolism, in an article titled "LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept." In vitro and in vivo validation of the triple agonist effect of LY3437943: Eli Lilly's research results show that LY3437943 demonstrates superior weight loss effects compared to GLP-1 receptor (GLP-1R) selective agonists (GLP-1 RA), GLP-1R and GCGR dual agonists (Cotadutide or 05677), and GLP-1R and GIPR dual agonists
A typical schedule: Weeks 1, 4 : 0.25 mg/kg/day (e.g., 20 mg for a 75 kg patient) Week 4 labs : if triglycerides remain below 300 mg/dL and ALT/AST are within 1.5x upper limits of normal, increase to 0.5 mg/kg/day Week 8 labs : if stable, consider escalation to 0.75 mg/kg/day Week 12+ : hold at the maximum tolerated dose until cumulative target is reached The initial flare (worsening of acne in weeks 2, 4) occurs in older adults just as it does in younger patients
Patients should be aware that smoking any substance carries inherent respiratory risks, including chronic bronchitis and impaired lung function
found "no adverse effects on blood clinical safety markers" in their 8-week study with resistance-trained males
Learn what it means, how schedules and charts work, and why a licensed providers guidance is key to the right dose
