do you have to taper off glp 1 Weaning GLP-1s: How Off Your GLP-1 How to Wean Off GLP-1

This table compares the active ingredients, FDA-approved usage, and typical weight loss or A1C reduction of some of the most well-known GLP-1s: Semaglutide vs tirzepatide Semaglutide is the active ingredient found in the injectable medications Ozempic and Wegovy (and the oral medication Rybelsus)

Choose nutrient-dense foods that keep you fuller for longer

A minimum of 1.2 grams of protein per kilogram of target body weight per day blunts the post-discontinuation hunger surge by maintaining satiety signaling and preserving lean mass

Tirzepatide after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial

Interpreting these results with a qualified healthcare provider can support a more personalized tapering timeline and lifestyle-intensity planning before and after discontinuation

In this case, the patient has achieved their goal weight, but their practitioner is wondering how to properly taper the dosage and whether full discontinuation has been successful for others