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A clinical trial demonstrated that oral sodium selenate supplementation increases brain Se levels without notable side effects, and participants with improved Se levels do not exhibit worsening Mini-Mental State Examination scores over time (108)

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Here, it has been demonstrated for the first time that SEMA, a GLP-1RA with known pharmacological effects on metabolic syndrome [43, 44], is able to reshape PDAC stroma preventing T lymphocyte exclusion by P4HA1-collagen-pCAF axis (Fig

Additionally, we observed enrichment of 22 genes related to seizure disorders, supported by evidence that GLP1R may suppress seizures through neuronal receptor regulation 63

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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a class of drugs approved for treatment of type 2 diabetes (T2D), overweight, and obesity