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In C2C12 myotubes, NNMT inhibitor treatment produces concentration-dependent increases in NADH levels (50% higher at 30 M) and reduces NAD+/NADH ratios by 25-40%

These can take a variety of forms, including injections, oral pills, skin-attached patches, slow-release drugs, and more

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When NNMT is too active, it consumes our precious supply of NAD+ (nicotinamide adenine dinucleotide), a coenzyme that is absolutely essential for cellular energy production and DNA repair

Initially, injections are given daily or every other day for a week, then weekly for 12 months, followed by monthly maintenance

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