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Developed by Eli Lilly, retatrutide is currently in Phase 3 clinical trials for obesity and type 2 diabetes

It decreases hippocampal levels of proinflammatory cytokines such as TNF, IL1, and IL6, while concurrently inhibiting NFB nuclear translocation and promoting an antiinflammatory microglial phenotype

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Concerning features may prompt assessment in line with NICE guidelines for suspected cancer (NG12)

(PubMed) Brion LP, Bell EF, Raghuveer TS, Soghier L