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Ahmed MS, Langer H, Abed M, Voelkl J, Lang F

Key Contraindications (Both) Active malignancy or recent cancer history, pregnancy, breastfeeding, uncontrolled diabetes, severe pituitary disease

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According to protein structure predictions 23 , they also adopt the thioredoxin fold, which puts the putative active site, a CCMC/S or CCLC/S motif, at the beginning of helix 1 (shown exemplarily for ROXY9 in Fig