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Despite numerous studies done in many patients none of them has been shown to be entirely devoid of inducing increases in plasma calcium or phosphate, and none has been demonstrated so far to be superior to calcitriol or alfacalcidol in controlling secondary hyperparathyroidism in the long run (285,286)

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Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term studies in animals to evaluate carcinogenic potential have not been done

La Rubia, M., Rus, A., Molina, F