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Heart failure symptoms (rare, mostly in those with underlying heart disease): Shortness of breath Swelling in ankles or feet Rapid weight gain

During wound healing, it can be removed from existing extracellular proteins by proteolysis and used as a chemical attractant for inflammatory and endothelial cells It can increase the production of messenger RNA in collagen, elastin, proteoglycans and glycosaminoglycans in fibroblasts

While rare, these require immediate medical attention

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Petasiteshybridus root (butterbur) is an effective preventive treatment for migraine