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doi: 10.3109/07357900903287048 219 SchallyAVVargaJL
In the ever-evolving healthcare landscape, pharmaceutical advancements continue redefining how we approach various health conditions
As for mortality, both SGLT-2 inhibitors and GLP-1RA are similar in reducing both total and CV deaths, but SGLT-2 inhibitors only are superior to DPP-4 inhibitors for both deaths, whereas GLP-1RA are superior to DPP-4 inhibitors for total death, but equal for CV death
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The Endocrine Society's 2023 clinical practice guideline on pharmacologic management of obesity notes that GLP-1 receptor agonists may affect oral drug absorption but emphasizes that "clinically significant reductions in efficacy have not been demonstrated for most co-administered medications" [7]
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