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It is also used for canker sores, cataracts, Alzheimer disease, osteoporosis, fatigue, and many other conditions

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Recovery is complex

Although rare, adverse effects of high-dose vitamin B12 have been reported, including allergic reactions such as fever, rash, itching, hot flushes, dizziness, and nausea, across all cobalamin forms and administration routes ( Intramuscular (IM) injection is the most invasive and costly administration method, requiring trained personnel and clinical visits

This makes oral delivery the preferred route for GI-specific indications, while injectable delivery is preferred for systemic tissue repair goals (joint, muscle, tendon, systemic inflammation)

TB-500 is commonly referenced in studies examining markers involved in blood vessel formation and vascular remodeling