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Its main mechanism appears to be its interaction with the nitric oxide (NO) system and its ability to upregulate growth factors like Vascular Endothelial Growth Factor (VEGF)

Zhang N, Sun Q, Zhang H, Cao Y, Weeda S, Ren S, et al

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This suggests that IL-8 may play a critical role in the early response to immunogenic and inflammatory signals with its response to nonspecific stimuli 38