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We thus predict that for both drugs, and for drugs targeted at reducing extracellular glutamate levels in general, there will be lower increases in the Glx/NAA ratio as well as reduced reductions in NAA levels associated with neuronal volume loss (Table 6)

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doi: 10.1186/s13045-023-01453-1 140 LingZ-NJiangY-FRuJ-NLuJ-HDingBWuJ

Zanders S, Sonntag Brown M, Chen C, Alani E

Therefore, developing local, controllable, and reversible therapeutic methods holds greater clinical advantages, but this largely depends on the development of more advanced delivery systems and precise monitoring protocols