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It clarifies whether reflux is truly present, whether there is a hypersensitive esophagus, or whether other factors are responsible for the symptoms that may not be directly attributable to reflux , emphasizes Prof

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The resulting inflammation and tissue damage can perpetuate the autoimmune response, creating a vicious cycle of oxidative stress and immune-mediated tissue injury [129]

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The NP in the puncture-only IVD group was not centered, with fissures extending into the AF