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As shown in Table 2, both BMI and LDL cholesterol were associated with GLP-1 receptor expression in univariate analysis, but in multivariate analysis BMI alone was significant determinant factor for GLP-1 receptor expression level and LDL cholesterol became non-significant for it

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This engenders a short-term desensitization of the receptor or internalization leading to long-term downregulation due to receptor degradation with a rate k d which ranges from hours to days [20]

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