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[58] proposed a metabolic trap hypothesis that suggests ME/CFS patients suffer from insufficient kynurenine production due to gene mutations in IDO2 [58]

Emerging evidence has suggested that mitochondrial dysfunction and ferroptosis are not uniformly engaged across the course of IDD but instead display stage-dependent features (32,33)

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In February 2026, Novo Nordisk announced it will slash US list prices by up to 50% for Ozempic, Wegovy, and Rybelsus effective January 2027, bringing the list price to $675/month ( [74] )

Elbarbary NS, Ismail EAR, Zaki MA, Darwish YW, Ibrahim MZ, El-Hamamsy M

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