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Large meals late at night can cause discomfort due to slowed gastric emptying

Average weight loss was ( 7.8 pounds (3.55 kg) for a 3.75/23 mg (phentermine/topiramate) dose 16 pounds (7.27 kg) for a 7.5/46 mg dose 18 pounds (8.25 kg) for a 15/92 mg dose In users of phentermine-topiramate, weight loss translated to a significant decrease in waist circumference as well as improved insulin sensitivity, improved blood sugar management, and reduction in blood pressure ( May be helpful for certain eating disorders The combination of phentermine and topiramate may help reduce binge eating in people with BED and bulimia nervosa

This massive reduction adds to the growing scientific evidence that GLP-1 drugs reduce addiction across substances

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