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Nature 541 , 4145 (2017)

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Berberine is generally well-tolerated at standard doses (1,000-1,500mg daily), but carries important considerations: Common side effects: Gastrointestinal upset (cramping, diarrhea, constipation) in 10-30% of users, typically resolving within 2-4 weeks 43 Yin, J

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30 Hoffman et al reported one of the most comprehensive epidemiological investigations conducted prior to 2000