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Cell 184 , 53575374.e5322 (2021)

PDK4 expression is high in heart, liver, pancreatic islets, and kidney and each of these tissues are capable of high rates of fatty acid oxidation and also express high levels of the transcription factors PPAR and PPAR which are known to be critical regulators of the expression of genes encoding lipid metabolizing enzymes

For now, indirect metabolic biomarkers remain the primary feedback mechanism

E., & Smith, A