Off-label or unlicensed use of medicines: prescribers' responsibilities
Based on the microglia transplantation approaches described (Table 2), it is appealing to hypothesize that bone marrow or hematopoietic cells could be modified ex vivo to express factors important for modulating an inflammatory response (such as IL-4, IGF-1, BDNF, GDNF) and/or blocking TLR/CD14 and then transplanted into ALS patients, taking advantage of the cells ability to migrate in the CNS (Fig
In others, real licensed pharmacies were named on labels but had never compounded those specific products
Given the more direct drug delivery route, intranasally delivered drugs have the potential to be more potent, work more quickly, be better targeted, produce less side effects and be more effective overall
J Endod 13:2939
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