Limited long-term and post-marketing data
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Amongst people with HF, up to 50% are estimated to have type 2 diabetes and, vice versa, around 20% of the over 500 million people living with type 2 diabetes have been shown to have comorbid HF (ClinicalTrials.gov IDs NCT04916470 and NCT04788511), it may be relevant to consider obesity-related HFpEF as a specific (sub)phenotype, whether coexisting with type 2 diabetes or not
the endpoints are weight, HbA1c, and other surrogates over trial-length follow-up
No comparable data exists for split dosing
Its a GLP-1 agonist medication proven to help people lose weight