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J Bioenerg Biomembr 29: 525531 McKernanTB,WoodsEB,LashLH (1991) Uptake of glutathione by renal cortical mitochondria

doi: 10.3389/fpls.2025.1425880 Received 30 April 2024 Accepted 09 January 2025 Published 20 February 2025 Volume 16 - 2025 Edited by Maria Raffaella Ercolano, University of Naples Federico II, Italy Reviewed by Eva Nouri, Universit de Fribourg, Switzerland Marija Vidovic, University of Belgrade, Serbia Updates Copyright 2025 do Carmo Santos, Silva Santos, Pereira Silva de Novais, dos Santos Lopes, Pirovani and Micheli

Such bidirectional interaction between hyperandrogenism and insulin resistance/hyperinsulinemia likely plays a key role in the pathogenesis of PCOS 12,13,14 , since elevated testosterone promotes obesity and insulin resistance/hyperinsulinemia by altering body composition and insulin signaling in skeletal muscle and adipose tissue, while hyperinsulinemia contributes to increase androgen levels via ovarian-dependent mechanisms 5

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Ali S, Corbi G, Maes M, Scapagnini G, Davinelli S