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While the G site is conserved across GST isoforms, the H site and other regions may vary, providing opportunities to create more selective inhibitors that minimize off-target effects
(PubMed) Moore CE, Sasidharan Pillai S, Austin J, Fredette ME, Serrano-Gonzalez M
Glutathione is a powerful molecule with antioxidant action that plays a leading role in the body's defense against oxidative stress and the action of free radicals and is able to protect hepatocytes from toxic molecules that could cause liver damage
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9,10 These oxidized forms are completely inactive, but they can be reactivated under reducing treatment with DTT at alkaline pH values