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Thus, the presence of LPS led to elevated serum LDL-C levels by activating TLR4 ( Statins-related potential pathways regulating cholesterol metabolism Statins and gut microbiota Statins are well known as the most commonly used cholesterol-lowering drugs, which can directly reduce plasma cholesterol levels, especially LDL-C (Table 2)

Sletten AC, Davidson JW, Yagabasan B, Moores S, Schwaiger-Haber M, Fujiwara H, et al

all of which can have a direct impact on immunogenicity 28, 29