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We found that the glycolytic flux into the TCA cycle was reduced in Gclc fl/fl Mb1-Cre + FoB compared to Gclc fl/fl FoB, as indicated by increased M3-lactate and reduced M2-citrate (Supplementary Fig

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In other words, NAD+ is a key component of the cellular energy generating system

The metabolites detected were acetaminophenglutathione and acetaminophencysteine with their pseudomolecular ions ([M + H] + ) at m / z 457 and m / z 271