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In Alzheimer's Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial

requires medical knowledge to minimize risk Intranasal Intranasal delivery to target the olfactory bulb and trans-cribriform access to the brain has been explored for some peptides: Theoretical advantage: Direct CNS access, bypassing the blood-brain barrier Reality: Intranasal peptide formulations are complex and Dihexa is not commonly available in this form Evidence: No published data on intranasal Dihexa efficacy or safety Oral Bioavailability: Approximately 38% The most commonly cited bioavailability figure for oral Dihexa is approximately 38%

Whether the heptapeptide fragment fully recapitulates the parent proteins effects in vivo remains an unresolved question

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