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muciniphila isolated from human feces significantly increases GLP-1 secretion from human enteroendocrine L cells (NCI-H716) in a dose-dependent manner and to a greater extent than the microbial products acetate and propionate (Yoon et al., 2021)

Elevated cAMP levels subsequently activate protein kinase A (PKA) and Rap guanine nucleotide exchange factor 4 (RAPGEF4, also known as EPAC2)

We include a couple extras of certain items since everyone is bound to have an oops! moment, especially anyone who has never injected themselves at home before

japonicum , has been found to significantly suppress the proliferation of murine myelomonocytic leukemia cell line (WEHI-3B JCS) cells in a dose- and time-dependent manner by inducing G1/G0 cell cycle arrest and apoptosis

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Our study describes a novel action of GLP-1 signalling in -cells, which stimulates metabolic/bioenergetic reprograming resulting in a high glycolytic/high ATP generating phenotype, as detailed in (Fig