PE-22-28 (Mini-Spadin) blocks TREK-1 potassium channels with ~100-fold greater potency than its parent compound, demonstrating BDNF upregulation, rapid neurogenesis within 4 days, and cognitive benefits in stroke models (Djillani et al., 2017 in Frontiers in Pharmacology)
3,417 adults with overweight or obesity but without type 2 diabetes
Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems
During the full time period (January 2018 June 2024), 73.7% of GLP-1 RA prescriptions had a dispense within 60 days of their prescription (e.g., were initiated within 60 days)
The label states that pancreatitis has been reported in clinical trials of the drug
Vitamin C and glutathione serums are used to brighten skin, combat aging symptoms, offer antioxidant protection, and enhance general skin health