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CGM, continuous glucose monitoring

This initial dose establishes baseline tolerance

While dura mater B cells, including immature B2 subsets, originate primarily from skull bone marrow, antigen-experienced B cells in the peripheral blood can infiltrate the meninges during aging [120]

In mitochondria, it protects the electron transport chain from oxidative damage, supporting efficient energy production and cellular longevity (NIH)

Haque SM, Rahman H, Rahman N, Azmi SN, Ashwaq O, Wabaidur SM, Siddiqui MR, Alam M (2023) Application of Box-Behnken design combined response surface methodology to optimize HPLC and spectrophotometric techniques for quantifying febuxostat in pharmaceutical formulations and spiked wastewater samples

This helps the treatment work best