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NICE guideline NG28 recommends GLP-1 receptor agonists for adults with type 2 diabetes who have inadequate glycaemic control despite optimal management with other glucose-lowering therapies and have a BMI 30 kg/m

Since brain GLP-1R signaling is to a large extent directly triggered by its peripheral secretion from the intestines via vagal stimulation of the NTS neurons, it seems plausible that proper balance in gut microbiota abundance and diversity can influence action of this peptide in the central nervous system

Yes, for most men with mild to moderate erectile dysfunction

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Inoki et al

Joint tissue resilience