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In summary, genetic risk factors for development of serious DILI at relatively low levels of APAP overdose seem likely to exist but the limited studies performed to date need to be followed up by genome-wide approaches using larger numbers of confirmed DILI cases or possibly further studies on volunteers showing transient ALT elevation
Three key elements are needed to trigger the ferroptotic pathway: 1) Polyunsaturated long-chain fatty acids (PUFAs) stored in phospholipid membranes 2) Redox-active iron 3) A defective lipid peroxide repair system
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id L, Zelek V, Girman V, Bednark J, Zelekov A, Szcsov J, et al