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Excessive production of RAGE on brain microvascular endothelial cells increases A transport into the brain tissue and decreases its removal, leading to the accumulation of A in the brain tissue, which in turn triggers a series of neurodegenerative pathological changes, such as the formation of amyloid plaques, the formation of neurofibrillary tangles, and the loss of neurons (23)

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21 When treated with a combination of L-methylfolate, methylcobalamin, and pyridoxal-5-phosphate (Metanx) for 24 weeks, diabetic patients had significantly reduced homocysteine and consistent symptomatic relief

Notably, calcium electroporation-a non-thermal ablation method-has shown efficacy in localized PCa treatment

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