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Shifting to every-other-day administration during weeks 46 reduces cumulative receptor occupancy and slows further desensitization while still maintaining therapeutic plasma IGF-1 LR3 levels, extending the effective anabolic window by 12 weeks compared to continuous daily dosing that plateaus completely by week 5

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They designed a 16-week prospective randomized open-label study with 30 men, with BMI 41.2 8.4 kg/m2 and aged 46.5 10.9 years

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The focus on weight loss often overshadows the critical element of body composition