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Abbreviations FSH: Follicle-stimulating hormone CNS: Central nervous system GnRH: Gonadotropin-releasing hormone cAMP: Cyclic adenosine monophosphate IGF: Insulin-like growth factors CREB: cAMP response element-binding protein hCG: Human chorionic gonadotropin PI3K/Akt: Phosphatidylinositol 3-kinase/protein kinase B MAPK/ERK1: Mitogen-activated protein kinase/extracellular signal-regulated kinases CYP19A1: Cytochrome P450 family 19 subfamily A member 1 References Adamson GD, Rutherford AJ (2018) Commercialization of in-vitro fertilization

Jensen et al., 2013

The reason these are not recommended is that they are not reversible