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He led the landmark STEP clinical trials for Novo Nordisk that brought semaglutide to market, co-authored the influential Lancet Commission framework distinguishing clinical from preclinical obesity, and has written multiple books on the subject including a phenotype-based guide for clinicians and the popular Six Factors to Fit

While this mechanism is exactly what helps you feel full longer and prevents blood sugar spikes, it can also lead to constipation for two primary reasons: Not enough fluid intake: When you feel full, you tend to drink less water

Treatment should be used alongside a reduced-calorie diet and increased physical activity for optimal weight loss outcomes

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doi: 10.3389/fphys.2020.00555