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For this reason, synthetic analogs of neurosteroids, which are more resistant to metabolism and better able to cross the BBB, are under investigation for use as anxiolytics, antidepressants, cognitive enhancers, anesthetics, and anticonvulsants (132, 388, 389)

Foot flexion contracture in the rats were evaluated and graded on a scale of 0-4 with 0 being no contracture

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