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Although the exact mechanism of how signaling kinases, such as MAPK, PKC, and PI3K, regulate the gene expression of GCLC and GCLM remains unclear, it is generally thought that these kinases act through direct phosphorylation of Nrf2, or other proteins involved in Nrf2-EpRE complex formation

Nevertheless, data generated from multiple groups have demonstrated the presence of senescent cells in postmortem human brain (Figure 1)

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Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway

npj Science of Learning

Journal of Neurochemistry