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High glutamine downregulates melanoma-associated oncogenes Low glutamine levels in tumour regions have been shown to induce upregulation of melanoma dedifferentiation genes via the inhibition of the KG-dependent JHDMs 1

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So, cysteinylated proteins taken up from the plasma by micropinocytosis can constitute a source of cysteine that once in the cell will be used in the different cysteine metabolic pathways, even in the s -cysteinylation of other proteins

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